AKR1C3 CLIA Kit for Human(Homo sapiens) | EIAab.comAKR1C3 CLIA Kit for Human(Homo sapiens) | EIAab.com

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AKR1C3 (Gene name),

Aldo-keto reductase family 1 member C3 (Protein name ), AK1C3_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

AKR1C3(DDH1;HSD17B5;KIAA0119;PGFS);

Protein name:

Aldo-keto reductase family 1 member C3;

Alternative:

1.1.1.239;Testosterone 17-beta-dehydrogenase 5);3-alpha-HSD type II, brain;1.3.1.20;Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase(17-beta-hydroxysteroid dehydrogenase type 5(17-beta-HSD 5);Chlordecone reductase homolog HAKRb;1.1.1.357;3-alpha-hydroxysteroid dehydrogenase type 2(3-alpha-HSD type 2);Dihydrodiol dehydrogenase type I;Dihydrodiol dehydrogenase 3(DD-3;DD3);1.1.1.112;Indanol dehydrogenase);HA1753;1.1.1.188;Prostaglandin F synthase(PGFS);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

323

Sequence:

50:

MDSKHQCVKL | NDGHFMPVLG | FGTYAPPEVP | RSKALEVTKL | AIEAGFRHID |

100:

SAHLYNNEEQ | VGLAIRSKIA | DGSVKREDIF | YTSKLWSTFH | RPELVRPALE |

150:

NSLKKAQLDY | VDLYLIHSPM | SLKPGEELSP | TDENGKVIFD | IVDLCTTWEA |

200:

MEKCKDAGLA | KSIGVSNFNR | RQLEMILNKP | GLKYKPVCNQ | VECHPYFNRS |

250:

KLLDFCKSKD | IVLVAYSALG | SQRDKRWVDP | NSPVLLEDPV | LCALAKKHKR |

300:

TPALIALRYQ | LQRGVVVLAK | SYNEQRIRQN | VQVFEFQLTA | EDMKAIDGLD |

323:

RNLHYFNSDS | FASHPNYPYS | DEY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

SMR:

Pfam:

String:

MIM:

KEGG:

Uniprot:

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ELISA Kit for Human Aldo-keto reductase family 1 member C3

Cat.:

E0603h

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MSDS:

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Packing:

96T

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CLIA Kit for Human Aldo-keto reductase family 1 member C3

Cat.:

U0603h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Aldo-keto reductase family 1 member C3

Cat.:

P0603Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Aldo-keto reductase family 1 member C3

Protein for Human Aldo-keto reductase family 1 member C3

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase."
Qin K.-N. , New M.I. , Cheng K.-C.
J. Steroid Biochem. Mol. Biol.46:673-679(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLN-5 AND ILE-175
tissue: Liver.
2.

"Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases."
Khanna M. , Qin K.-N. , Wang R.W. , Cheng K.-C.
J. Biol. Chem.270:20162-20168(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];CHARACTERIZATION;TISSUE SPECIFICITY;VARIANTS GLN-5 AND ILE-175
3.

"Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans."
Khanna M. , Qin K.-N. , Cheng K.-C.
J. Steroid Biochem. Mol. Biol.53:41-46(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLN-5
tissue: Liver.
4.

"Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution."
Lin H.-K. , Jez J.M. , Schlegel B.P. , Peehl D.M. , Pachter J.A. , Penning T.M.
Mol. Endocrinol.11:1971-1984(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;TISSUE SPECIFICITY;VARIANT GLN-5
tissue: Prostate.
5.

"cDNA cloning, expression and characterization of human prostaglandin F synthase."
Suzuki-Yamamoto T. , Nishizawa M. , Fukui M. , Okuda-Ashitaka E. , Nakajima T. , Ito S. , Watanabe K.
FEBS Lett.462:335-340(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-190;CHARACTERIZATION;TISSUE SPECIFICITY;VARIANT GLN-5
tissue: Lung.
6.

"Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes."
Griffin L.D. , Mellon S.H.
Proc. Natl. Acad. Sci. U.S.A.96:13512-13517(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;VARIANT GLN-5
tissue: Brain.
7.

"Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes."
Nishizawa M. , Nakajima T. , Yasuda K. , Kanzaki H. , Sasaguri Y. , Watanabe K. , Ito S.
Genes Cells5:111-125(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Liver.
8.

"Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3)."
Penning T.M. , Burczynski M.E. , Jez J.M. , Lin H.-K. , Ma H. , Moore M. , Ratnam K. , Palackal N.
Mol. Cell. Endocrinol.171:137-149(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;TISSUE SPECIFICITY
tissue: Prostate.
9.

"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLN-5
tissue: Bone marrow.
10.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
11.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Tongue.
12.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
tissue: Urinary bladder.
15.

"Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase."
Dufort I. , Rheault P. , Huang X.-F. , Soucy P. , Luu-The V.
Endocrinology140:568-574(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;TISSUE SPECIFICITY;CHARACTERIZATION OF VARIANT ILE-175;MUTAGENESIS OF LYS-75
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Crystal structure of human prostaglandin F synthase (AKR1C3)."
Komoto J. , Yamada T. , Watanabe K. , Takusagawa F.
Biochemistry43:2188-2198(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH PROSTAGLANDIN H(2); NADPH AND RUTIN
18.

"Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin."
Lovering A.L. , Ride J.P. , Bunce C.M. , Desmond J.C. , Cummings S.M. , White S.A.
Cancer Res.64:1802-1810(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH FLUFENAMIC ACID AND INDOMETHACIN
19.

"Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues."
Qiu W. , Zhou M. , Labrie F. , Lin S.-X.
Mol. Endocrinol.18:1798-1807(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH NADP AND DELTA4 -3 ANDROSTENE-3,17-DIONE;IMPORTANCE OF TRP-227 AND PHE-306 IN LIGAND RECOGNITION AND PRODUCT RELEASE

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